Coating Drug-Eluting Stents
Coating Drug-Eluting Stents – Ultrasonic Automization System – Cheersonic
Monitoring of the drug release process in the physiological environment is a crucial aspect of an effective treatment technique. A time-programmed drug release can make a balance between the drug release to the artery lumen and the drug absorption by the surrounding artery tissue. The key is to choose the right system for delivering medicine. The rapid rate of drug release might exceed the tissue uptake. In contrast, a slow release rate could delay the tissue-healing process. Contemporary coronary stent technology continues to improve the performance of previous-generation devices by enhancing their design, structure, and component materials. These technologies include:
1. new generations of drug-eluting stents,
2. nonpolymeric stents,
3. bioresorbable polymer-coated stents
4. fully bioresorbable scaffolds.
Stents can be ideal drug delivery systems, because they allow local releasing of the active ingredient into the vascular damaged area. Besides, the drug released from the stent can have the capability to inhibit the complex cascade of events that lead to building a new tunica intima after stent implantation . The potential objectives of therapeutic interventions are to limit the proliferation of the new intimia, to define inflammatory and proliferative mechanisms associated with the healing process, and to induce vascular repair processes specific to the blood and vascular wall.
The commonly used stent coating technology can be ultrasonic coating, which sprays polymer and drug solutions (using various solvents) onto the stent, so that a uniform drug release layer can be uniformly deposited on the surface of the stent. Ultrasonic nozzles have the advantage of penetrating complex stent geometries, ensuring complete coverage of all pillar surfaces without the need for webbing. The soft atomized spray can adhere well to the surface, and the morphological characteristics of the coating can be adjusted by modifying the process parameters. The advantage of the ultrasonic spraying system is that the coating formed by dip coating is much thinner, can save spraying materials to a large extent, and the nozzle is not easy to be blocked.
UAM3000 is a high-performance stent spraying equipment developed for stent series products, mainly used for drug coating on the surface of stents. The special nozzle for ultrasonic stent with national patent can realize accurate application of medicine, and the fixture specially equipped for stent is convenient for loading and unloading. This device has the characteristics of supporting multiple series and multiple types of stents, high drug utilization, accurate drug delivery, and high uniformity of the stent membrane layer.
Video of Precision Ultrasonic Stent Coating Machine
