Absorbable Occluder
Absorbable Occluder – Medical Device Coatings – Cheersonic
Ventricular septal defect is a common congenital heart disease, accounting for about 30-50% of all congenital heart diseases. In normal people, the left ventricle and the right ventricle are separated by the interventricular septum and do not communicate with each other. If the ventricular septum is not fully developed during the fetal period and a hole is left, which makes the left ventricle communicate with the right ventricle, and produces a left-to-right shunt at the level of the ventricle, it is called a ventricular septal defect. Long-term shunt will cause pulmonary hypertension and seriously threaten the life of the patient.
Interventional occlusion is one of the common methods for the treatment of ventricular septal defect. It has the advantages of less trauma and quick recovery. However, the occluder implanted in the human body is made of metal and remains permanently in the patient’s body, which can cause various long-term complications. Complications, and some patients with metal allergy will have chronic inflammation, commonly known as “foreign body reaction”. Absorbable occluder is a “black technology” to solve the above problems, and it is also a hot spot of research in the global cardiovascular field. Around 2010, the world’s major medical device manufacturers invested a lot of money and technology in research and development, but due to absorbable materials No development under radiation, researchers had to add metal parts to the occluder to ensure that the occluder can be implanted into the body under the guidance of radiation, but these non-absorbable metal parts fall off during the absorption process and cause embolism, etc. A series of new complications, so the clinical trials of the absorbable occluder developed in the early stage have failed successively, and the research and development of the absorbable occluder has been in trouble.
Later, scientists adopted interventional methodology to bring a new dawn to the development of absorbable occluders. Non-radiation-guided interventional technology does not rely on radiation at all. Ultrasound-guided interventional therapy can clearly display absorbable materials in the human body without metal markers. It can implant a “completely absorbable” occluder, which solves the “key pain point” in the development of absorbable occluders. The invention of this technology has made absorbable occluders a hot spot in research and development again.
On the basis of technological innovation, the scientists used poly-dioxanone (PDO) and poly-L-lactic acid (PLLA) to balance the degradation speed and endothelialization speed of the occluder. At the same time, the clinical team designed a unique molding line to solve the problem of Due to the poor elasticity of the absorbing material and the difficulty in shaping the occluder, a new type of occluder was finally developed, and animal experiments were completed in 2017.
Ultrasonic nozzles are particularly suitable for a wide range of medical coating applications due to their very precise, non-blocking, repeatable spray performance and extremely low flow rate capability. For several years, Cheersonic has been providing ultrasonic medical coating system to medical device manufacturers worldwide. As medical device technology evolves, we will continue to design unique medical coating ultrasonic spray solutions to enhance patient safety and provide the highest quality medical device coating on the market.
