Coating Drug-eluting Balloons

Coating Drug-eluting Balloons – Spray Coating Equipment – Cheersonic

Drug-eluting Balloons are conventional semi-compliant angioplasty balloons covered with an antirestenotic drug which is released into the vessel wall during inflation of the balloon, usually at nominal pressures with a specific minimal inflation time. The active substance on the Drug-eluting Balloons should be lipophilic enough to have a high absorption rate through the vessel wall to compensate for the short period of contact between the inflated balloon and the vessel wall itself, and to maintain a sustained effect once released. The drug of choice at the moment is paclitaxel. Paclitaxel is a broad-spectrum antimitotic agent that inhibits cell division in the G2/M phase, stabilising the polymerised microtubules and thus inhibiting cell replication of the smooth-muscle cells, thereby reducing neointimal hyperplasia. Paclitaxel was identified as the primary drug for Drug-eluting Balloons owing to its pharmacological characteristics, such as its high lipophilic properties and its ability to remain in the vessel wall for nearly a week. Thus, stent- and polymer-driven sustained drug release may not be necessary in all cases.

Ultrasonic Balloon Catheter Coating System is suited to coating high pressure medical balloons with drug eluting polymers such as Paclitaxel and other bioabsorbable drugs for dilation procedures including coronary angioplasty or stent delivery applications.

The Balloon Catheter Coating System is a fully enclosed, sealed glovebox unit designed to coat common sizes and types of balloon catheters using Cheersonic ultrasonic nozzles combined with our UAM7000 precision air shaping systems. The spray pattern diameter and drop size are variable, depending upon the nozzle and air shaping system used. A proprietary holding device secures both ends of the catheter while rotational motors spin the catheter for 360Ocoverage of the entire balloon surface. The ultrasonic nozzle traverses across the catheter as required to coat desired lengths. The system includes controls for air flow rate, air pressure as well as continuous digital metering of humidity and temperature.

Paclitaxel Coated PTA Peripheral Balloon Catheter