Ensuring Uniformity Drug Effective Capsules

Ensuring Uniformity Drug Effective Capsules – Cheersonic

1. Electrostatic Spraying Technology

Principle: Electrostatic spraying utilizes a high-voltage electrostatic field to orient charged drug particles onto the capsule surface under the influence of the electric field. In this process, the drug solution is atomized into tiny charged droplets. The capsule is grounded, acting as an electrode. Droplets with opposite charges are driven towards the capsule by the electric field, thus achieving drug deposition.

Advantages: This technology allows for a more uniform distribution of drug particles on the capsule surface. Due to electrostatic adsorption, drug droplets can better adhere to the concave and curved parts of the capsule, effectively improving coating uniformity for capsules of different diameters and shapes. For example, for capsule sections with smaller diameters or complex curved surfaces, electrostatic attraction helps drug droplets overcome the effects of surface tension and other factors, resulting in more uniform coverage of these areas.

Precautions: However, it is crucial to control the strength and uniformity of the electrostatic field during electrostatic spraying. An uneven electrostatic field may lead to uneven drug distribution on the capsule surface. Simultaneously, it is crucial to ensure the balloon material can withstand the effects of an electrostatic field without damage, and to take precautions against potential safety issues arising from sparks generated by electrostatic discharge, especially when using flammable drug solvents.

2. Ultrasonic Atomization Spraying Technology

Principle: Ultrasonic atomization uses high-frequency ultrasonic vibrations to break the drug solution into tiny droplets. These droplets are smaller and more uniformly distributed, allowing for a finer coating of the balloon surface during spraying. The energy of the ultrasound waves helps to create a stable atomization state of the drug solution at the nozzle, reducing the formation of large droplets.

Advantages: For drug balloon spraying, ultrasonic atomization technology helps improve coating uniformity, especially for small-diameter balloons and applications requiring high-precision coatings. It produces uniformly sized droplets, resulting in a more uniform film of drug on the balloon surface. Furthermore, ultrasonic atomization can be performed at lower spraying pressures, reducing physical impact on the balloon and making it suitable for balloons of various diameters and materials.

Precautions: When using ultrasonic atomization technology, it is necessary to select an ultrasonic generator with appropriate frequency and power to ensure effective atomization of the drug solution. Different drugs and solvents may respond differently to ultrasound, requiring adjustments based on the specific circumstances. Furthermore, the nozzle design of the ultrasonic nebulizer is crucial; it must ensure that the atomized droplets are evenly sprayed onto the balloon surface, avoiding localized areas of excessively high or low concentrations.

About Cheersonic

Cheersonic is the leading developer and manufacturer of ultrasonic coating systems for applying precise, thin film coatings to protect, strengthen or smooth surfaces on parts and components for the microelectronics/electronics, alternative energy, medical and industrial markets, including specialized glass applications in construction and automotive.

Our coating solutions are environmentally-friendly, efficient and highly reliable, and enable dramatic reductions in overspray, savings in raw material, water and energy usage and provide improved process repeatability, transfer efficiency, high uniformity and reduced emissions.

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